Classification of B-Cell Lymphomas and Immunodeficiency-Related Lymphoproliferations: What’s New?

New insights from genomic studies have had an impact on the definition and diagnosis of several lymphoid tumors including follicular B-cell lymphomas, aggressive diffuse large lymphoproliferations associated with acquired posttransplant immunodeficiencies. Follicular lymphoma (FL) includes whose behavior varies widely indolent/early lesions to aggressive/transformed lymphomas. Although some lymphomas can be subclassified as specific entities, majority lack characteristics necessary for subclassification and, thus, are termed lymphoma, NOS. There been, however, changes in classification subtypes well addition new a few which highlighted this article. The immunodeficiency-related lymphoproliferative disorders currently divided into four major categories based clinical setting they arose: primary immune deficiency, post-transplant, HIV infection, iatrogenic immunosuppression. In two upcoming classifications systems hematolymphoid neoplasms, International Consensus Classification (ICC) WHO-HAEM-5, there is divergence approach categorize these lesions. Furthermore, whereas WHO-HAEM-5 confirms ability classify spectrum EBV+ DLBCL, NOS, ICC has separated out that composed heterogenous cellular infiltrate separate category, “EBV-positive polymorphic B cell disorder, NOS”. Both recognize number KSHV/HHV8-associated acknowledge significant overlap among different future, translation innovations general practice requires further validation.